Category: Badania

CBD and serotonin

CBD and serotonin

Recently we examined in details how CBD interacts with the endocannabinoid system.This interaction is very complex and involves different ways of cannabidiol binding to receptor as well as its indirect effects (the most important being its impact on anandamide). On this occasion we mentioned that the effect of the most important cannabinoid of hemp on the human body is far more complex and not limited to interaction with the dedicated endocannabinoid system – it includes surprising impact on such different and diverse systems as the vanilloid, adenosine, dopamine, and even opioid systems. Continuing our mini-series, today we will look into the mechanism of how CBD interacts with one of the most important and comprehensive systems regulating a whole plethora bodily functions – the serotonin system. It’s been only recently that we started to recognize, let alone understand the impact CBD has on this system (as is the case with many of the cannabinoids’ less-obvious interactions), so although many findings suggesting that serotonin plays an important role in the beneficiary and medicinal properties of cannabidiol, there is no way yet to identify the exact mechanism and extent of this beneficial impact. Along with the complex nature of the CBD’s interaction with other systems, this proves just how complex and potent the substances from the natural pharmacopoeia can be. More »

CBD to THC conversion in the gastrointestinal tract – debunking myths

CBD to THC conversion in the gastrointestinal tract – debunking myths

Cannabis and Cannabinoid Research published a paper in response to a biased article sponsored by the pharmaceutical company Zynerba Pharmaceuticals, Inc., a manufacturer of synthetic gel spreads containing synthetic CBD. The article commented on in the said paper suggested that in the stomach CBD is transformed into THC (1). The eponymous stance of “Even High Doses of Oral Cannabidiol Do Not Cause THC-Like Effects in Humans: Comment on Merrick et al.” article (2) was very well backed with research, debunking the myth particularly disturbing for parents of children with epilepsy which is treated with relatively high doses of CBD. The parents’ fears are in fact justified as if CBD-THC conversion actually did take place on a large scale they might be worried about such a mechanism’s consequences in the future. More »